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1.
Sci Rep ; 12(1): 19435, 2022 Nov 13.
Article in English | MEDLINE | ID: covidwho-2119152

ABSTRACT

A mathematical model is presented in this paper to investigate the effects of time delay in vaccine production on COVID-19 spread. The model is analyzed qualitatively and numerically. The qualitative analysis indicates that the system variables are non-negative, bounded, and biologically meaningful. Moreover, the model has produced two equilibrium points: the free equilibrium point, which can exist without conditions, and the endemic equilibrium point, which can exist if the control reproduction number, [Formula: see text], is not less than one. In addition, the local stability of the equilibrium points is investigated and agrees with the numerical analysis results. Finally, a sensitivity analysis is conducted for [Formula: see text]. In particular, we examine the effect of the vaccine's time delay, vaccine rate, and vaccine efficiency on the model dynamics.


Subject(s)
COVID-19 , Humans , Basic Reproduction Number , Computer Simulation , COVID-19/prevention & control , Vaccination , Models, Theoretical , Models, Biological
2.
Math Biosci Eng ; 19(10): 9792-9824, 2022 07 08.
Article in English | MEDLINE | ID: covidwho-1964171

ABSTRACT

Saudi Arabia was among the countries that attempted to manage the COVID-19 pandemic by developing strategies to control the epidemic. Lockdown, social distancing and random diagnostic tests are among these strategies. In this study, we formulated a mathematical model to investigate the impact of employing random diagnostic tests to detect asymptomatic COVID-19 patients. The model has been examined qualitatively and numerically. Two equilibrium points were obtained: the COVID-19 free equilibrium and the COVID-19 endemic equilibrium. The local and global asymptotic stability of the equilibrium points depends on the control reproduction number Rc. The model was validated by employing the Saudi Ministry of Health COVID-19 dashboard data. Numerical simulations were conducted to substantiate the qualitative results. Further, sensitivity analysis was performed on Rc to scrutinize the significant parameters for combating COVID-19. Finally, different scenarios for implementing random diagnostic tests were explored numerically along with the control strategies applied in Saudi Arabia.


Subject(s)
COVID-19 , Communicable Disease Control , Humans , Pandemics , SARS-CoV-2 , Saudi Arabia
3.
PLoS One ; 17(4): e0265779, 2022.
Article in English | MEDLINE | ID: covidwho-1789180

ABSTRACT

The COVID-19 pandemic spread rapidly worldwide. On September 15, 2021, a total of 546,251 confirmed cases were recorded in Saudi Arabia alone. Saudi Arabia imposed various levels of lockdown and forced the community to implement social distancing. In this paper, we formulate a mathematical model to study the impact of these measures on COVID-19 spread. The model is analyzed qualitatively, producing two equilibrium points. The existence and stability of the COVID-19 free equilibrium and the endemic equilibrium depend on the control reproduction number, [Formula: see text]. These results are in good agreement with the numerical experiments. Moreover, the model is fitted with actual data from the COVID-19 dashboard of the Saudi Ministry of Health. We divide the timeline from March 12, 2020, to September 23, 2020, into seven phases according to the varied applications of lockdown and social distancing. We then explore several scenarios to investigate the optimal application of these measures and address whether it is possible to rely solely on social distancing without imposing a lockdown.


Subject(s)
COVID-19 , Pandemics , COVID-19/epidemiology , COVID-19/prevention & control , Communicable Disease Control , Humans , Pandemics/prevention & control , Physical Distancing , Saudi Arabia/epidemiology
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